When you try to scroll through webpages with the hand instead of the scroll bar.

When you tell your significant other you'll be right to bed after this harvest comes in... and don't understand when they come back later to complain... until you realize it's light outside.

Waking up in the middle of the night to check on your villagers. (Even worse if you set the alarm clock for it, which I haven't done... but have thought about.)

Actually trying to explain to friends and family that you can't go out because you have a weakened villager... and while yes, there is a pause button... you can't really use it.