This is the first I've heard that someone lost money/entire save game. Saving something in VST with PT open will zap all the seeds in the VST but VST does not delete your save game.

I'm not sure what the heck happened. One suggestion is to look in your save game folder for the backup of your save game and rename it to the save game.

Another suggestion is to make regular backups of your save games.

LadyCFII, have you had any reports of people using VST losing their entire game? any thoughts?

Whether it was VST that caused you to lose your game or not, I am very sorry you lost your game. If I could replace it for you, I would.