Do you mean Lewanda's mod
here? I suppose the only way to know is to try it out and see. I
think the heads and bodies files have the same names in both games, so it might work. You would of course have VF1 peeps in your VF2 game, but presumably that would be OK. What I don't know is if the image files map precisely - that there are the same number of possible peeps in both games. It is also possible that VF2 peeps can move their heads and/or bodies slightly differently to the ones in VF1 and the image files don't include that particular action. In some cases peeps might have a blank space where the image didn't load properly.
If you do decide to try it out make doubly sure you've backed up the original image files first so you can restore them easily if there's a problem, and let us know how you got on!