Sounds like maybe your having problems keeping your savegame files where they are, if you move or delete the files from the "my document" folder in your c drive, you wont be able to open the game, Is there anyone else in the house that might be doing this, or maybe you were doing it not realizing that it was essential, even if you move to a new folder or a sub folder, the game wont be able to find it.
Sometimes our cleanup programs and spam protectors delete unnessasary files and since its not nessasary to run the acual computer it may be deleting it, are you finding that it happend after you did a clean? i know youve been here for awhile, but sometimes the simplest thing is the one thing you never think of.
Just a question, did you run VV1? did you ever have problems with it. or is VV2 the first game youve played.