I will have to guess that your save game files are corrupt. You can try two things:

1. Try re-installing the game and see if that works. You will want to backup your save game files first just to be safe. If that does not work, then;

2. The first thing I would try is copy all your current save games into a backup folder. Your save game files are in a folder called "LDW" which is in "My Documents". After you have copied those files to a safe place, delete them. Then try running VV2 again. If VV2 loads then your save game files are corrupt. If so Barbra can help you try and save them, but they might be lost for good.