What kind of error? Which version are you installing (LDW or BFG?)?

It runs fine, in general, on Vista. Let's figure this out!

One thing you can try right away is to go into your harddrive into Program Files->Virtual Villagers - The Lost Children, and click the exe there. If that works, then just make a shortcut from that to your desktop. Please keep me informed so I know what is going on here...I might need to adjust/fix the installer.