I get sad for my first 20-25, which are the ones I raised. But, after that, not really, because I have so many villagers I grow detached. I remember one that I HATED in VV3 though. Her name was Yasa and she didn't do ANYTHING! I tried and tried, but she stayed in the middle of the village, not doing anything.
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I'm going to take the time right now to plug my fanfics. Aspen's story and Lilihia and the Tree.