Nice work! I hope newer players find it helpful.
I (like Lyssa,) have a few things to add:
Tiny boxes tend to contain ants. Don't open them.
Ants, the cheap trainer and power outages are all very nice for cleaning out the fridge so you can change to organics. They are useful first when you finally have enough money to begin purchasing all organics, then after the beginning of each new generation to clean out old food and avoid the "we need some different kind of groceries" email.
Once in a while you'll get a benevolent neighbor who'll give you a hammock. The notice will arrive by email. (On a related note, the same neighbor will occasionally send you emails that rare collectibles are in your yard. But don't rely on this all the time.)
The rare collectible from the email ALWAYS appears immediately upon your closing the email. Rares seem to not stay on screen as long as commons, so I suggest you pick up the person who read the email and immediately start around the yard with them to find the rare. If you have difficulty seeing collectibles and do not have a mod installed to make them more visible, you can immediately pause the game and the rare will remain on the screen as long as that window remains active (for windows users.)
You have to have at least 3 (preferably 4 or 5) mature people in the house to be able to use wall compound before it dries up.
I've repaired the wall quite a few times with only the first two adults of a family. You just have to watch them continually and not let them wander off, as they will only complete one round of repairing, then try to do another action.
DON'T move your peeps when they're bringing a new collectible to the collectible cabinet, but you can move them when they are selling one. The money will be automatically credited to you.
You can move them as soon as they stand up with the collectible "in hand." Regardless of whether it should go in the chest or be sold, it is yours once they stand up with it and will be immediately credited when/if you pick them up. Just don't open another family or close the game until it is sold or put in the chest.
The rule of kid beauty contests: if you think the kid's ugly, they probably won't win. But if they're pretty/handsome they probably will. (This is learned solely from experience. One of my virtual kids came in 8th out of 7... ouch) But, this could just be random. I don't really know yet.
I have one entire windows user in which I have entered the contest every single time the event has come up for all families. They have NEVER won and have received the "8th place" notification every single time. I can't say it isn't possible, but I have never heard of anyone winning the contest.
Once in a while the "family fun magazine" will drop by to say your photo is featured in their magazine. There's nothing you can do to make this happen more often... it just happens.
You are given a monetary reward for the photo and the amount of money you receive is random.
Peeps picking up a wrapper/sock, if interrupted, will drop it where they last were. But, peeps interrupted while picking up the remote will drop it back where it originally was.
Weeds will also be dropped where they were interrupted. Several people like to praise them for picking up trash/socks/weeds and collectibles in the belief that it affects happiness levels. (No matter how much you praise,they can never "learn" to do these actions on their own.) The remote seems to be affected by different programming. If you praise a peep who is returning the remote, you are actually praising a "hidden" action that they are doing "underneath" carrying the remote. Therefore, praising them for returning the remote is not recommended.
I know this is obvious... but kids tend to look like their parents. So much so that one of my families was made solely of girls that looked exactly like their mom and boys that looked exactly like their dad.
There is an entire thread devoted to studying the "genetics" of VF. Children will most often fall within a certain distance of their parents on the "head" image file, although occasionally a child outside of that range will be born.
Profession magazines don't provide a visible boost in the career progress bar, but they will eventually help. They got one of my peeps to a level 8 career.
The profession magazines pretend your peep has done one work cycle (from what I've seen) so this will have a greater visual impact on the lower levels of your peep's career.
I cannot give an exact amount because the bar does not give us numerical measurements, but I am almost certain the magazines give a random amount of career experience. I have most definitely had one take a brand new adoptee from Beginner to Novice (which is a lot more than one work cycle) and I had a newly married couple at almost the exact same level that had both magazines appear in the store. I gave each of them a magazine - one acquired a promotion plus experience for the next level, and the other remained a small bit away from a promotion.
If a stranger comes to the door and will sell you career tips for $5, reject him. He will eat all your food.
Again, getting rid of food is only a bad thing in early generations when you are poor. If you have plenty of money for groceries, it is actually a good thing to clear the old food out of the fridge. This is actually the BEST way to completely clear out the food and start over, as this event empties the fridge more than any of the others. (See above.)
If the trainer charges $250, he is a professional trainer and your lil peep will get a promotion if you pay him.
If there's a power outage, don't throw out your food if you have a lot, but beware... it can increase the rate of sickness in the household.
See above.
If someone gets sick a lot, try the penicillin first, then the vancomycin. Both will get you trophies if matched with the correct illness. But, if you have enough money, go with the doctor consultation to be sure.
You can actually tell which antibiotic they need by how fast they get sick again, so there is no need to guess and buy both. If the symptom IMMEDIATELY returns after you give them the correct medicine for it, they need vanco. If they get sick again a short time after being sick and receiving the correct medicine from the store, they need penicillin.
If you buy your peeps a different outfit, the new clothes won't show up in the family tree. They'll look like they did pre-clothing change.
Actually the new clothes will appear on the family tree, as will the changes in like and dislikes, if (and only if) that child is chosen to begin the new generation. Their picture and description at the beginning of the new generation will have the updates.
Yes, there are only 4 plates on the table. No, it's not a bug. Yes, they have to eat in shifts. Oh well.
Even though there are only 4 plates, 5 can eat at the table at once (so if you have more than 5 in the home, they have to eat in shifts.) The "missing plate" is the reason I (personally) choose to see the dishes as "serving dishes" rather than plates. I decided a long time ago that they must eat on plates so small I can't see them.

It's better than thinking one person gets left out.
Peeps tend to die at 65. You can try to get them to reach that goal by a) keeping them happy and fed and b) buying them vitamins/food/hand sanitizer.
My average age at death is 68 (as best as I can calculate, since the game does not tell us how old they were when they died.) It fluctuates depending on how many families I am playing and how much time I am actually able to spend playing. If I am here enough to give them 3 meals a day and continue training them to exercise, they live to 70 easy enough. I think it has a lot to do with how and what you train them to do, as well as organics (for getting a couple of extra years) and the things you mention.
If your elderly peeps are slow picking up weeds, you can buy the weed bomb (very helpful), although you may have to wait a while.
Just keep in mind that if you still need to weed trophies, weeds killed with a bomb are not counted.
Edit: Here are a couple of others that I haven't put into any guides (or guides in progress) yet:
If you want to get someone to take a nap when they are exhausted, drop them on the treadmill. (Naps restore energy faster than "Going to Bed", especially during the day.)
Perfumes, colognes and professional magazines are great for restoring happiness after the loss of a spouse. (Even if your peep is maxed in career, the magazine seems to restore more happiness than anything else I have tried, including candy.)
Keep energy drinks on hand to restore energy after giving antibiotics. There's no need to make your lil peep miss out on working on their career because the antibiotic took all their energy. The drink is a quick fix. If you don't have a drink, don't let them go to bed unless it's night. Make them nap instead - it's faster.
Thanks for the tips!