I don't know if this would help any, but have you done a medical consultation on at least Penni, maybe Vic too? I know you said you have tried baby boost, but maybe it will be more effective if it is recommended by the doctor. I could be way off on this, but since you are desperate to keep this family going, I would suggest doing a medical consult and, if it recommends baby boost, give them another shot of it and keep trying. Of course, at their ages, it may still not work, but one never knows. GOOD LUCK!