To help increase her mood, first check out her likes and dislikes. They may provide you with some helpful information. If she "Definitely" wants children and doesn't have any yet. that is probably what is wrong with her happiness level. As Arnie suggested, she or the hubby may need baby boost. But you may also need to boost her happiness for a successful attempt at a baby as well.
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Next try candy. Give her some candy instead of the green glove when she is doing something you want to praise for. You may have to wait for it to be available in the store. Other store items can make them a bit happier as well, but candy is the biggest boost. If candy isn't available, try sunscreen, movies, even perfume and weather bottles (especially the sun.) It's better to save fruits for in case someone gets sick and you need to boost their health, but if all else fails, you can give her those as well. Some little people just get happier when you buy stuff and give it to them.

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