I've been pausing a lot, since my gaming habbits are quite irregular and I don't want to miss their important moments. Though I never wrote down the actual details and checked them later, I'm pretty sure that such irregularities never occured in my game. I find the food levels, energy and health bars unchanged (or not noticably changed) when I unpause the game. But once, a nursing mother let her kid go right after I unpaused, and once I unpaused the game, clicked on a peep and his status changed to hungry from elated right in front of my eyes (but he hadn't have a meal for some time already). I just assumed that these things were about to happen anyway, so I didn't care that much.

But I remember that in VV, some things were kind of triggered by exiting and reopening the game, such as nursing moms letting their kids go. If I remember right there was a three minutes' check time about that, and reopening forced the game to do that check earlier. So I'm thinking, maybe, these things in VF are caused by similar reasons.