I try to get them to make babies later in the afternoon so the mother can work most of the day, and rest during most of her non working time. Hard slave driver I am!
However, I find as they are more tired in the afternoon, the less success I've had with them having a baby. I seem to get them to have a baby a lot easier when they are more active & have heaps of energy, so keep persisting as everyone has said, and try during their more active times, at least from my experience.
A few couples I did have trouble getting to six children, but most times I did manage it unless the mother was an older mother at the start of the game. That only happened to me once.