I move the brush over my pet. If you do that, your pet will react to your brushing - like "wiggling" his body - to show that he likes it. To administer the meds, just drag the syringe onto your pet and release it. Be VERY careful with the meds - I killed my first pet from a drug overdose (before I saw Carla's post on the subject). I guess I was just too familiar with Fish Tycoon - fish don't die of drug overdoses!!