If you pause the game before you have over 2000 food points, your villagers will die if you don't get to play as much. I put them on slow with better results.
If you pause the game, your villagers won't die because nothing will be happening to them. I've had one tribe on pause for one week now and they are still fine and still paused. I think you mean if you let the game run on Normal or Fast, then the villagers might die if you don't check in on them often enough.