I have been playing for 152 real hours. I have full tech in fertility and spirituality, level two in everything else. For a long time I only had 2 females, knowing my game was almost over, I was surprised to get a boy in a box. Now he is the only one alive. The women died before he was old enough to breed. Is there any hope. I have too much invested to stop. I have 6 puzzles solved.

There is hope, although it's not guaranteed. There are at least two other Island Events that could bring potential companion(s)/mate(s) to help rescue your lone boy. I never give up until I get the "game over" message!