Yes.

It's almost impossible to completely finish a VV game. Perhaps all the puzzles have been solved and everything has been built, but you'll probably still have a few collectibles to find or achievements to reach. By that time the peeps are pretty well self-sufficient and are quite likely to keep going without supervision. I've gone back to (espcially VV1 and VV2) tribes a year or so after leaving them alone and found them still active. Usually, after a few generations and some TLC I've got them back to full strength again.

I'll generally start new games at quite widely spaced intervals so that they are at different stages in their development, which adds interest. I haven't actually uninstalled any games, but over the years I've changed computers and in some cases haven't reinstalled them all.